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Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions

41,252 At the same time, viral particles infect neighboring young cells through paracrine or humoral diffusion, spreading the senescence phenotype to the whole body through the mechanism of contagious aging, resulting in a cascade of amplification effects

doi: 10.1002/dmrr.488 100

In this study, we show that both GAC and GLS2 undergo filament formation in the presence of the substrate glutamine and the activator inorganic phosphate, with the assembly of this higher-order oligomer being tightly coupled to glutamine hydrolysis and product (glutamate) release