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While federal and state efforts to close these gapssuch as redefining hemp to include all THC isomershave faced political challenges and industry pushback, the regulation of hemp-derived cannabinoids remains inconsistent and vulnerable to exploitation

All animal studies were conducted following protocols approved by local ethical committees and French regulatory authorities (#03860.07, Committee CELYNE APAFIS#187 & 188, Committee DARWIN APAFIS#5516-2016053017288535, APAFIS #38705- 2022092718027606)

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Al-Tammemi Faculty of Pharmacy, Philadelphia University, Amman, Jordan Yazan Al Thaher School of Pharmacy, Cardiff University, Cardiff, UK Yazan Al Thaher Research Group in Health Economics, Universidad de Cartagena (University of Cartagena), Cartagena, Colombia Nelson Alvis-Guzman Research Group in Hospital Management and Health Policies, Universidad de la Costa (University of the Coast), Barranquilla, Colombia Nelson Alvis-Guzman Department of Rehabilitation Sciences, Jordan University of Science and Technology, Irbid, Jordan Mohammad Al-Wardat Fakeeh College for Medical Sciences, Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia Yaser Mohammed Al-Worafi College of Medical Sciences, Azal University for Human Development, Sanaa, Yemen Yaser Mohammed Al-Worafi Department of Pediatrics, Cleveland Clinic, Cleveland, OH, USA Hany Aly Department of Pharmaceutical Sciences, Qatar University, Doha, Qatar Karem H