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For example, when cardiomyocytes were incubated with the taurine transporter antagonist (guanidinoethane sulfonate-GES) or taurine transporter inhibitor (-alanine), mitochondrial oxidative stress increased and was accompanied by an accumulation of superoxide anions (O2), glutathione oxidation (GSSG), and inactivation of anti-oxidant enzymes such as aconitase (46,50)

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5 Selective autophagy and ferritinophagy in lesion redox control Autophagy is a critical cellular quality control process with a complex, double-edged role in cell fate: it can promote survival by recycling damaged components or contribute to cell death under specific forms of stress