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Surgical procedures have become much more precise and aim at preserving important anatomical and functional structures, although this does not guarantee better results because long-term data of modern procedures will only be available in 1015 years

There is substantial evidence that APR-246s effect on the redox system contributes considerably to its mechanism of action [20, 26, 46], and that this triggers ferroptosis [27,28,29] independent of p53 status [47]

The authors concluded that APCP intake improved skin moisture, increased ceramide and NMF contents in the SC, and enhanced skin barrier function [37]

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