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& Pereira, N

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Seventeen metabolites differed significantly in dogs with DCM eating NT versus traditional diets (e.g., fatty acids, amino acids, legume biomarkers), suggesting different mechanisms for primary versus diet-associated DCM

Furthermore, -hydroxybutyrate serves as the primary source of acetyl-CoA in T cells, facilitating H3K27ac at promoters of effector gene loci (e.g., Ifng , Gzmb and Tbx21 ), thereby augmenting cytokine production in CD8 + T cells (e.g., IFN-, TNF-) and modulating cellular immune functions