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Preclinical evidence suggests gastroprotective and anti-inflammatory properties for BPC-157 [2]

[48] Fructose + 2 ATP 2 G3P + 2 ADP Fructose and hexokinase In addition to the hepatic fructokinase pathway, extrahepatic tissues can also metabolize fructose through the action of hexokinase, albeit with a markedly lower affinity for fructose than for glucose

If a patient does not respond to the first-line therapy (amitriptyline, cyproheptadine, and/or propranolol) the following options should be considered: (1) presence of persisting triggers (e.g., psychological stressors) and comorbid conditions (e.g., anxiety, POTS) or missed underlying disorders (e.g., hydronephrosis, chronic sinusitis, acute appendicitis, intestinal malrotation with volvulus, CNS tumors, metabolic crises) and toxic exposure (e.g., cannabis)

Another advanced treatment is NAD+ IV therapy, which helps improve energy levels and supports cellular repair