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Acknowledgements We extend our gratitude to Sheng Wan from the Department of Dermatology, Third People's Hospital of Hangzhou, for his invaluable assistance in the immunofluorescence experiments

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89 Conventionally, GDH (coded by the GLUD gene) is the more predominant enzymes vital for the reactions needed to replenish the TCA cycle and yield NADPH than GOT2 and GPT2, which consists of ubiquitously expressed GDH1 and GDH2 mainly existing in neuronal and testicular tissue and having lower activity than GDH1

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