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1 DFU DFU is the advanced consequence of multiple factors, including uncontrolled hyperglycemia, DPN and peripheral arterial disease (PAD)

When the CNS is damaged, a subsequent cascade of pathological reactions is induced by primary injuries that involve an increase in excitatory amino acids, calcium overload, blood-brain barrier damage, apoptosis, and oxidative stress (Wang et al., 2011

Habert R, Lejeune H, Saez JM: Origin, differentiation and regulation of fetal and adult Leydig cells

Furthermore, we validated on drug penetration into cells, putting forward that the internalization of our nano-machinery may be mediated by TLR2