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In rigorous research, requirements are: complete analytical control (HPLC 98%, MS identity, Cu ratio for GHK-Cu, formulation stability), adapted experimental models (primary fibroblasts, explants, in vivo photoageing or wound models), exhaustive documentation for publication

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however, the Pro-Gly-Pro C-terminal extension significantly enhances metabolic stability compared to native tuftsin, and downstream signaling effects persist well beyond plasma clearance

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