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2022;114:e110493

The pattern suggests that each additional receptor target provides incremental but meaningful improvements

It also phosphorylates SREBP-1c at Ser372, which inhibits proteolytic maturation, nuclear translocation of SREBP-1c and the expression of downstream fatty acid synthase gene, thus increasing fatty acid -oxidation and reducing de novo synthesis of TG (25) to prevent hepatocyte steatosis by reducing the accumulation of TG in HepG2 cells (26)