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sALS and fALS share several features, including protein aggregation, motor neuron hyperexcitability, trafficking defects, disruption of nucleocytoplasmic transport, oxidative stress, mitochondrial dysfunction, glutamate excitotoxicity, and neuroinflammation

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The potential for pain can impact an individuals performance of day-to-day activities and decrease his/her quality of life (1)

Therapeutically targeting tumor cell metabolism have been proven effective with fewer side effects compared to some conventional treatments