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Furthermore, the threshold eect is consistent with the concept that methionine synthase activity may become saturated beyond a cer- tain B12 concentration [17], explaining the diminishing returns observed at higher levels

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This means for 340B covered entity hospitals that acquire NDCs through the 340B program, they are to submit up to four fields of information for each NDC depending on their acquisition patterns: total net acquisition costnon-340B, total units purchasednon-340B, total net acquisition cost 340B, total units purchased 340B