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451,452 The agonists of the sirtuin family have been widely studied since the discovery of the first SIRT1 agonist, resveratrol, in 2003

doi: 10.1136/gut.29.7.941 85 RondeauMPMeltzerKMichelKEMcManusCMWashabauRJ

These findings suggest possible bidirectional interaction between CDI and the ENS

Tributyrin inhibited the increase in plasma triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels and increased the portal vein butyrate level in mice