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doi:10.1002/14651858.CD003678.pub3

Clinical indications include deficiency due to inadequate diet or malabsorption, drug-induced deficiency (for example, from long-term isoniazid or oral contraceptives), and certain inborn errors of metabolism (such as pyridoxine-dependent seizures or sideroblastic anemia)

This vital characteristic makes it absolutely essential for controlled research settings that require repeated solution handling, dose-variation studies, and extended observation over a defined period (typically up to 28 days post-reconstitution)