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Moreover, the majority of these peptides do not penetrate deep within the skin and do not carry risks for systemic side effects [3, 16, 26, 30, 37]

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This process can ultimately result in weight gain and an increase in peripheral fat mass ( 3.2 Biguanide Biguanides are a pharmacological and pharmaceutical class that relies on the biguanidine molecule ( 3.2.1 Adverse effects of biguanide Symptoms of the gastrointestinal tract (e.g., nausea, vomiting, diarrhea, and abdominal discomfort) are among the side effects linked with the therapeutic use of all biguanides ( Lactic acidosis is an uncommon but possibly hazardous metformin adverse effect

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