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auris ) utilised amino acid metabolism including arginine, cysteine, and methionine metabolism potentially improving their competitive fitness in pathogenesis

Use fresh diluent and maintain strict sterility throughout reconstitution and injection

This metabolic normalisation would subsequently attenuate lactate-dependent histone lactylation and its transcriptional activation of pro-fibrotic genes such as TGF-1 and -SMA, ultimately diminishing renal interstitial fibrosis signalling pathways [34, 35]

Even with this apparent specificity, it is difficult to rule out the possibility that stimulation could induce several anterograde and retrograde effects, and they could be local or long-distance [389]