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Rapid correction of acidosis with sodium bicarbonate in patients with diabetic ketoacidosis may cause hypokalemia, paradoxical acidosis in cerebrospinal fluid (CSF) since carbon dioxide diffuses more rapidly into CSF than does bicarbonate, and lactic acidosis since increased pH increases hemoglobin-oxygen affinity which, when combined with erythrocyte 2,3-diphosphoglycerate (2,3-DPG) deficiency in these patients, results in peripheral tissue hypoxia

Also called pigmented cosmetic contact dermatitis

It is present in every cell but especially concentrated in the liver where it plays a major role in phase II detoxification, the stage in which glutathione binds to toxic molecules to prepare them to be removed from the body

This along with the hosts immune system poses a substantial redox stress on the intraerythrocytic development of the parasite