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The increase in Ca 2+ ultimately activates insulin granular docking and releasing from the ready releasable pool 123 (Fig

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7.1.5 Modulation of innate immunity and TLRs signaling The initial interaction involves the recognition of microbe-associated molecular patterns (MAMPs), such as peptidoglycan and lipoteichoic acid, by TLRs expressed on intestinal epithelial cells and DCs (237)