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Advise patients and caregivers: how to treat with the overdose reversal agent in the event of an opioid overdose to tell family and friends about the opioid overdose reversal agent, and to keep it in a place where family and friends can access it in an emergency to read the Patient Information (or other educational material) that will come with their opioid overdose reversal agent

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COMT, catechol-O-methyltransferase

Later, the same group discovered that mice that lacked NFB in astrocytes had reduced Mn-induced glial activation and neuronal loss ( in vitro and in vivo , while LRRK2 deletion in microglia reduced cytokine release in vitro (Kim et al., 2019)