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This would lead to decreased number of SSBs and reduce the probability for an occurrence of DSBs resulting from the accumulation of SSBs

and its moderation of copper toxicity

The increased flux of acetyl-CoA will then build up the levels of Krebs intermediates including fumarate and succinate (also inhibitors of prolyl hydroxylase), especially if the biotin-dependent pyruvate carboxylase cannot sustain the production of oxaloacetate, the most limiting substrate of the cycle

Since Asians made up only a fraction of the examined participants, the authors speculate that a more balanced distribution of participants might alter the overall results