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Ultimately, personalized diagnosis and phenotyping are only effective if they guide targeted interventions that overcome the historical barriers of drug delivery and non-specificity

However, inhibition of fungal glutaminases at high salt concentrations during fermentation leads to unwanted conversion of glutamine to pyroglutamic acid

Next-generation microbial therapeuticsincluding defined bacterial consortia, engineered probiotics, and targeted metabolite therapiesare expanding the therapeutic landscape (OToole et al., 2017)