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Previous study showed that MMP-2 and MMP-9 prompt CNV by degrading and remolding endothelial basement membrane and extracellular matrix [51]

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Zelber-Sagi S., Lotan R., Shlomai A., Webb M., Harrari G., Buch A., Kaluski D.N., Halpern Z., Oren R

For instance, just as bisphosphonates and denosumab are used to manage cancer-related hypercalcemia by inhibiting bone resorption (143), copper-chelation and ionophore-based therapies are being explored to modulate copper levels and induce selective cancer cell death (214,215)

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