glutathione in ros Reactive Oxygen Species (ROS) Metabolic Disease—Don't Shoot the Metabolic Messenger NOX-like ROS production by glutathione

Therefore, in order to contextualize the complexity of the metabolic network and the impact of Gclc on it, we analyzed our transcriptomic data using Compass, a flux balance analysis-based approach that allows the characterization and interpretation of metabolic diversity at the single cell level 70,71

Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo JQ, Boonplueang R, Viswanath V, Jacobs R, Yang L, Beal MF, DiMonte D, Volitaskis I, Ellerby L, Cherny RA, Bush AI, Andersen JK (2003) Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinsons disease

Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism

We have already discussed the fundamental role of GSH in avoiding ROS accumulation leading to cancerous transformation, as well as its crucial role in tumor cells survival