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The CP is initiated by C1q binding to antigen-antibody complexes, thereby inducing a cascade via C2 and C4 cleavage, leading to the production of CP C3 convertase (C4b2b)

304-306 In a retrospective analysis of patients with mild cognitive impairment, the effect of melatonin on sleep, mood, and several tests of cognitive function was reported

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Fibrinogen-Mimetic Nanoplatforms: Platelet-activatable nanoparticles (e.g., RGD-Chi@tPA) enhance thrombus targeting and tissue plasminogen activator penetration for efficient thrombolysis [110](Figure 6)