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Two parallel pathways connect glutamine metabolism and mtorc1 activity to regulate glutamoptosis

In addition, presence of high concentrations of polyunsaturated fatty acids in the brain enhances their peroxidation and generation of toxic products which further causes degeneration of the cells harboring them or in vicinity 22

Diabetes (2010) 59:1059

Selenium Essential for glutathione peroxidase function Selenium's antioxidant role centers on its incorporation into selenoproteins, particularly glutathione peroxidase: Enables glutathione peroxidase to convert hydrogen peroxide to water, preventing cellular damage Supports thioredoxin reductase, which helps maintain cellular redox balance Works synergistically with vitamin E to protect cell membranes May help prevent DNA damage through antioxidant action Selenium's effectiveness depends on adequate intake (55 g/day for adults) and proper incorporation into selenoproteins