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Alternative diagnoses and diagnostic categories include, but are not limited to: Neuromuscular disorders (such as myopathic EDS and Bethlem myopathy) Other heritable connective tissue disorders (such as other types of EDS, LoeysDietz syndrome, Marfan syndrome) Skeletal dysplasias (such as osteogenesis imperfecta) Classical EDS (cEDS) If a person meets the diagnostic criteria for cEDS, genetic testing should be done to confirm the diagnosis

During perimenopause, estradiol levels drop and estrone becomes the main form of estrogen

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The second option is exemplified by blocking of components of the complement system in diseases where complement deposition is driving pathology