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Stopping the medication can lead to rapid deterioration in glycemic control and may complicate the interpretation of test results

In skeletal muscle, the association between fusion and enzymatic activity in OXPHOS may limit mtDNA defects to the local regions of muscle fibers, which are often associated with mitochondrial myopathy (44)

When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals

[PubMed] [Google Scholar] 20.Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, Panayotou G, Waterfield MD, Ponzetto C, Pelicci PG