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The influence of substance use on adolescent brain development

Inhibition of GLS expression results in reduced immunoglobulin (Ig) G and IgM antibody production, and glutaminase blockade decreased downstream mTOR activation and attenuated IL-10 secretion [121, 141, 142]

Although it is hard to ascertain the cause of pyroglutamic acidosis because most of the reported patients had multiple medical comorbidities and/or kidney dysfunction or kidney failure, all of the patients were using APAP