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METHODS A literature search was carried out through PubMed/MEDLINE for all studies, randomized controlled trials, systematic reviews, meta-analyses, and review articles of NAC published up to February 2019

Consequently, the balance between xCT/GPX4 activity and ROS/iron/MDA levels determines cellular fate, with dysregulation tipping the scale toward ferroptotic cell death

The compound is referenced across a wide spectrum of preclinical models, with most literature focusing on three thematic areas: Skin biology: Studies on dermal fibroblast behaviour, collagen and elastin synthesis pathways, and extracellular matrix remodelling Gene expression modulation: Research examining the compounds reported activity across thousands of genes in genome-wide expression studies Antioxidant & copper transport: Models exploring its role as a physiological copper carrier and free radical interaction The 50mg and 100mg vial formats make GHK-Cu particularly suitable for extended research protocols where higher peptide volumes are required compared with the typical 510mg formats used for other research compounds

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