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Deng S, Li J, Li L, Lin S, Yang Y, Liu T, et al

Researchers and institutions should consult current regulatory filings before incorporating any of these compounds into clinical or performance-related study designs

In particular, TMAO is accumulated in one half the concentration of urea in shallow-sea elasmobranchs to counteract the deleterious effects of urea on cellular proteins (Seibel and Walsh, 2002)