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Alterations in these enzymes led finally to the depletion of GSH levels resulting in oxidative damage of the nerve tissue in the present study as sup- ported by ultrastructural studies

Despite these promising findings, DSIP remains largely experimental, with formal clinical approval, standardized dosing, and long-term safety data still lacking

Microbiome-directed probiotic interventions have shown promise in preclinical and clinical studies, ameliorating UC through multiple mechanisms, including anti-inflammatory activity, epithelial barrier restoration, and remodeling of the intestinal microbiota