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Serious adverse events have not been widely reported, but this may reflect the relatively small number of people who have used the compound and the limited reporting mechanisms available

261 In an uncontrolled trial in 47 subjects with fibromyalgia, 400 mg of oral SAMe twice daily plus 200 mg of intramuscularly injected SAMe once daily for six weeks decreased tenderness, increased general well-being, and improved scores measuring depression, anxiety, and mood

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I plan to get my second dose on schedule, at 4 weeks