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J Physiol Pharmacol 60(Suppl 7):107114 Ilic S, Drmic D, Zarkovic K et al (2010) High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats

Despite the high prevalence of OA, the mechanisms of OA-related pain are still not fully understood, so prescription drugs suggested by international guidelines for OA management can only relieve the pain for symptoms (99101)