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At 0.5%, suppression begins to fail within 7-14 days

at China Pharmaceutical University and Nanjing First Hospital: oral Dihexa restored spatial learning and memory in the APP/PS1 transgenic mouse model of Alzheimers disease via the PI3K/AKT signaling pathway, reduced neuroinflammation, and preserved hippocampal synaptophysin expression (Sun et al., Brain Sciences 2021)

Skronska-Wasek, W

Because of this disproportionate effect on the elderly, ambient temperatures can often be thought of as hastening a death that was very likely to occur in the coming weeks to years regardless of the temperature, a phenomenon known as mortality displacement or harvesting. This is evident statistically by noting that excess deaths after non-optimal temperatures are often followed by a period of below-normal deaths