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10.1038/nature05978 46 DaviesM

The avirulence of efg1 / cph1 in vivo does not necessarily have to be associated with pathogenicity towards host tissues but may rather relate to a reduced fitness during encounters with immune cells

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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits