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Biotechnol Adv 54:107795

Forty-six patients were randomly separated into ALA group, which received 1200 mg ALA or placebo group, which received placebo per day for 12 weeks

For instance, the pathogenic V122I variant of the protein transthyretin can induce cardiomyopathy due to destabilization of the transthyretin quaternary structure, i.e., the tetramer-folded monomer equilibrium, and an increased rate of tetramer dissociation [73]