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50 50 & Target IC50: 1.2 M (TRPM-1) [1] In Vitro ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation

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Available data from transgenic mice with liver-derived IGF-I deficiency clarified that IGF-I deficiency per se can promote the development of an accelerated cardiovascular aging phenotype