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Description

Luteolin-mediated PI3K/AKT/Nrf2 signaling pathway ameliorates inorganic mercury-induced cardiac injury

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rat (Schertz et al., 2018)

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While extensive animal studies exist, human data is extremely limited and lacks rigorous clinical trials

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In this review, we summarize rodent models of CIPN, the applicability of animal behavioral tests, and our current understanding of pathogenic mechanisms underlying the development of CIPN

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