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This is the central regulatory problem that full FDA approval would need to solve and it is the reason PCAC reviews for peptides like BPC-157 often hinge on available safety data rather than efficacy evidence from controlled human studies

showed that in response to ischemia in mouse brain, astrocytes and endothelial cells up-regulate the expression of the inflammatory chemoattractant stromal cell-derived factor 1 (SDF-1) [210]