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10.1016/j.freeradbiomed.2022.09.015 2 AlroujiM.AnwarS.VenkatesanK.ShahwanM.HassanM

CD4 + CD25 + FoxP3 + Tregs are essential for maintaining peripheral tolerance, and their depletion leads to spontaneous autoimmune disease in both mice and humans ( More recently, the Notch signaling pathway has emerged as a key modulator of Treg biology and a potential contributor to immune dysregulation