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Loss of complement inhibition initiates the classic complement pathway, which cross talks with the kallikrein kinin system (KKS)

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Another source of toxicity of herbal medicines that is important to mention is adulteration of herbal products with undeclared pharmaceutical drugs and potentially toxic compounds such as harmful molecules present in other adulterating botanicals, pathogenic microorganisms, toxins, pesticides, agrochemical residues, and heavy metals (e.g., lead, mercury, and arsenic) (Saper et al., 2004