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Methotrexate-loaded nanoparticle DNA scavengers (cNP-pp-PEG) have been developed to directly reach the core of inflammation, which not only mitigate systemic toxicity possibly induced by the strong positive charge of cationic nanoparticles (cNPs) during intravenous circulation but also enhance the therapeutic effect of cNPs (93)

The biodegradation of many sulfur compounds, including Cys, often results in the generation of hydrogen sulfide, which has an unpleasant odor 21,22

doi: 10.1007/s00068-007-7152-z 63 DouZ.RongX.ZhaoE.ZhangL.LvY

Regardless of all the above, all patients diagnosed with MASLD should be strongly encouraged to adopt primarily non-pharmacological interventions, with particular emphasis on promoting a healthy lifestyle, maintaining a balanced diet, and engaging in regular physical activity in order to reduce the risk of MASLD progression and associated adverse outcomes.