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Ntalapascha, Melpomeni, et al

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Under normal conditions, microglia maintain neuronal function through synaptic pruning, but in early AD, hyperactive neurons trigger aberrant microglial phagocytosis, causing synaptic loss and disrupted neural signaling (Zhong L

These metabolic changes underpinning neutrophil activity in inflammatory environments are primarily regulated by the cooperative action of NF-B [43, 223], HIF1 [224, 225], and mTOR [211, 226]