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If pain is a combination of emotional, cognitive, and social components versus just being a physical one, how could that affect how you would treat it as opposed to treating it like a physical problem

Repeated administration of berberine inhibits cytochromes P450 in humans

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The anxiolytic effects are comparable to benzodiazepines, but without the addiction potential, sedation, or cognitive blunting that makes benzodiazepines problematic for long-term use