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(2021), a minimal total sample size of 20 participants (10 in each group), is needed to determine the difference between the two study groups in biomarkers serum levels on day 7, using two-sample T test power analysis that detect a difference of 4 ng/mL between both groups that achieves 80% power with a significance level of 5%

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Resorcinol 0.3% serum is superior to vehicle, as concluded in a double-blind, randomized, vehicle-controlled split-face comparative trial ( LOE 2 ).[87] In another double-blind split-face RCT, 4-n-butylresorcinol (4-n-BLR) 0.1% cream was better than vehicle.[88] Similar results have been documented when a preparation of liposome-encapsulated 4-n-BLR 0.1% cream was compared with vehicle.[89] Tranexamic acid Efficacious alternative to HQ products, with comparable results

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