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As the side effects can be minimized by increasing the dose slowly, topiramate was administered at the lowest dose effective

Garland et al

Another metabolically relevant compound that links carnitine and CoA derivatives is the malonyl-CoA that is required for fatty acid biosynthesis but acts as a potent inhibitor of the carnitine acyltransferases using cytoplasmic substrates, such as carnitine palmitoyltransferase 1 (CPT1), which is the first component of the mitochondrial carnitine shuttle (Ramsay and Arduini, 1993)

Las sales de Sodio y Potasio, junto a Manitol y Sorbitol le confieren propiedades diurticas, facilitando la eliminacin de los metabolitos resultantes de la actividad heptica