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In such an experimental setting, where [MNA + ]/[MNAH TOT ] is constant but the Nernstian term [MNA + ]/[MNAH] is changing, the theoretical curve of the electrode potential versus pH is given by the following function, as [MNAH] can be expressed from equation (9): where K is the protonation constant of MNAH

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Its location on the apical (luminal) membrane of cholangiocytes, as well as the large increase in cAMP-stimulated CFTR activity observed with secretory agonists, suggests an important role of CFTR in bile formation [13]