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This generally involves inserting a cannula into a vein, usually in the arm, and slowly and controlled administration of the solution into the venous system

At the time of dispensing the spray shots, a vacuum line controlled by a flow-valve was used to set up inhalation airflow through the model, and the flow rate was commensurate with the subject-specific breathing data (Table 1)

Therefore, damage to hepatocytes in the presence of PLP deficiency could lower the activity of aminotransferases released into the circulation

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