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However, a subsequent randomized placebo-controlled trial by Hauser et al

One of the cleaner ones, a 24-week randomized study of 279 mild-to-moderate Alzheimers patients, tested three doses against placebo and found a result no marketer would have designed: the lowest dose, 10 mL a day, beat placebo on both a cognitive scale and a global clinical rating, while the higher 30 and 60 mL doses improved the global rating but not cognition (Alvarez et al., Eur J Neurol 2006, randomized controlled trial)

In 1907 along came Richard Clarke Cabot with his report on 1200 patients with Pernicious Anaemia

They comment that patients tend to prefer oral administration over injection for reasons of convenience and adherence