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POX expression is induced by the tumor suppressor p53, and ectopic expression of POX in DLD-1 colon cancer cells induces cell cycle arrest and reduces tumor burden in xenograft models [56]

More recently, in vivo proteomic approaches of SCI have demonstrated that peripheral nerve injury alters the expression and/or subcellular distribution of some specific dorsal horn proteins, for example those involved in nociceptive signaling, cellular metabolism, plasma membrane receptor trafficking, oxidative stress, apoptosis and degeneration (Lee et al., 2003